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ESSENCE meets the ASSURED (Affordable, Sensitive/No false-negatives, Selective/No false-positives, User-friendly, Rapid, Equipment-free and Delivered) criteria set by World Health Organization for point-of-care diagnostics, unlike most current state-of-the-art biosensors that cannot satisfy one of the above criteria. In ESSENCE, the flow through a nanoporous electrode results in

  • An enhanced shear force of the order of the hydrogen bond that makes the biosensor very selective, and prevents non-specific adsorption, false positives, and biofouling

  • Reduces the diffusion time (rapid) of the analyte to the sensor,

  • Negates the effect of the parasitic double layer capacitor to increase sensitivity and avoid false negatives

  • Allows in-situ regeneration of the robust sensor

  • Decouples sensitivity and selectivity

Current Publications

Compiled_4-02

Compiled_4-02

Figure 3

Figure 3

(A) Typical Nyquist Curve for Randles circuit, (B) Nyquist Curve fitting from our sensor

Figure 4

Figure 4

Comparison between batch, semi batch and chip sensitivity

Figure 5

Figure 5

(A) Raw EIS signal from binding event of an antigen to an antibody in our system and (B) normalized, processed signal

Figure 6

Figure 6

Sensor calibration curve against p53 (target antigen) and HER2 (non-target antigen)

Figure 7

Figure 7

Detection of p53 and HER2 from mixed p53 and HER2 samples

Mehnaz Mursalat, Monica Torralba, Bhuvana Mohanlal, Tulika Das, Malavika Krishnamurthy, John Frederick, Roli Kargupta, Tushar Gupta, Nikhil Koratkar, Stephen Suh, Sagnik Basuray, "A nanoordered shear tunable Biosensor, "ESSENCE", for Sensitive and Selective Detection of Cancer Biomarker" (to be submitted soon)

ESSENCE Biosensor

nsf-logo_640x480

nsf-logo_640x480

Mehnaz

Mehnaz

Compiled_4-01_edited

Compiled_4-01_edited

Figure 6

Figure 6

Compiled_4-02

Compiled_4-02

Figure 4

Figure 4

Figure 5

Figure 5

Andrew

Andrew

Figure 3

Figure 3

Figure 7

Figure 7

Basuray.Sagnik

Basuray.Sagnik

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