ESSENCE meets the ASSURED (Affordable, Sensitive/No false-negatives, Selective/No false-positives, User-friendly, Rapid, Equipment-free and Delivered) criteria set by World Health Organization for point-of-care diagnostics, unlike most current state-of-the-art biosensors that cannot satisfy one of the above criteria. In ESSENCE, the flow through a nanoporous electrode results in

• An enhanced shear force of the order of the hydrogen bond that makes the biosensor very selective, and prevents non-specific adsorption, false positives, and biofouling

• Reduces the diffusion time (rapid) of the analyte to the sensor,

• Negates the effect of the parasitic double layer capacitor to increase sensitivity and avoid false negatives

• Allows in-situ regeneration of the robust sensor

• Decouples sensitivity and selectivity